WEKO3
インデックスリンク
アイテム
{"_buckets": {"deposit": "3be0493e-2567-4736-b885-57cd7c0e9716"}, "_deposit": {"created_by": 18, "id": "8732", "owners": [18], "pid": {"revision_id": 0, "type": "depid", "value": "8732"}, "status": "published"}, "_oai": {"id": "oai:fukuyama-u.repo.nii.ac.jp:00008732", "sets": ["782"]}, "author_link": ["45538", "45621", "45620", "45616", "45615", "45619", "45617", "45614", "45618", "45081", "45075"], "item_10002_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2014-12-25", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "32", "bibliographicPageEnd": "19", "bibliographicPageStart": "18", "bibliographic_titles": [{"bibliographic_title": "福山大学薬学部研究年報"}, {"bibliographic_title": "Annual report of the Faculty of Pharmacy \u0026 Pharmaceutical Sciences, Fukuyama University", "bibliographic_titleLang": "en"}]}]}, "item_10002_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "9,10-Phenanthrenequinone (9,10-PQ) is one of the most abundant quinones among diesel exhaust particulates. Recent data have suggested that quinones induce apoptosis in immune, epithelial and tumor cells, leading to respirator illness; however, the mechanisms by which quinones induce apoptosis and the structure required for this remain unknown. We studied the antitumor activity of 9,10-PQ analogs against two human tumor cell lines, HCT-116 colon tumor cells and HL-60 promyelocytic leukemia cells. The loss of the cis-orthoquinone unit in 9,10-PQ abrogated its ability to induce apoptosis in the two tumor cell lines, and the LC50 values of these analogs were indicated over 10 μM. An analog of 9,10-PQ in which the biaryl unit had been deleted displayed a reduced ability to induce tumor cell apoptosis, while the analogs 1,10-phenanthroline-5,6-dione (9) and pyrene-4,5-dione (10), which also had modified biaryl units, exhibited increased tumor cell apoptotic activity. The cis-orthoquinone unit in 9,10-PQ was identified as essential for its ability to induce apoptosis in tumor cells, and its biaryl unit is also considered to influence orthoquinone-mediated apoptotic activity.", "subitem_description_type": "Abstract"}]}, "item_10002_description_6": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "9,10-Phenanthrenequinone (9,10-PQ) is one of the most abundant quinones among diesel exhaust particulates. Recent data have suggested that quinones induce apoptosis in immune, epithelial and tumor cells, leading to respirator illness; however, the mechanisms by which quinones induce apoptosis and the structure required for this remain unknown. We studied the antitumor activity of 9,10-PQ analogs against two human tumor cell lines, HCT-116 colon tumor cells and HL-60 promyelocytic leukemia cells. The loss of the cis-orthoquinone unit in 9,10-PQ abrogated its ability to induce apoptosis in the two tumor cell lines, and the LC50 values of these analogs were indicated over 10 μM. An analog of 9,10-PQ in which the biaryl unit had been deleted displayed a reduced ability to induce tumor cell apoptosis, while the analogs 1,10-phenanthroline-5,6-dione (9) and pyrene-4,5-dione (10), which also had modified biaryl units, exhibited increased tumor cell apoptotic activity. The cis-orthoquinone unit in 9,10-PQ was identified as essential for its ability to induce apoptosis in tumor cells, and its biaryl unit is also considered to influence orthoquinone-mediated apoptotic activity.", "subitem_description_type": "Other"}]}, "item_10002_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "福山大学薬学部"}]}, "item_10002_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN10064550", "subitem_source_identifier_type": "NCID"}]}, "item_10002_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0288-724X", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "波多江, 典之"}], "nameIdentifiers": [{"nameIdentifier": "45615", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "中村, 純"}], "nameIdentifiers": [{"nameIdentifier": "45616", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "奥島, 鉄雄"}], "nameIdentifiers": [{"nameIdentifier": "45617", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "石倉, 稔"}], "nameIdentifiers": [{"nameIdentifier": "45614", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "9000318134967", "nameIdentifierScheme": "CiNii ID", "nameIdentifierURI": "http://ci.nii.ac.jp/nrid/9000318134967"}]}, {"creatorNames": [{"creatorName": "阿部, 匠"}], "nameIdentifiers": [{"nameIdentifier": "45538", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "9000248213387", "nameIdentifierScheme": "CiNii ID", "nameIdentifierURI": "http://ci.nii.ac.jp/nrid/9000248213387"}]}, {"creatorNames": [{"creatorName": "日比野, 俐"}], "nameIdentifiers": [{"nameIdentifier": "45081", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "9000014453717 ", "nameIdentifierScheme": "CiNii ID", "nameIdentifierURI": "http://ci.nii.ac.jp/nrid/9000014453717 "}]}, {"creatorNames": [{"creatorName": "町支, 臣成"}], "nameIdentifiers": [{"nameIdentifier": "45075", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "9000005189344", "nameIdentifierScheme": "CiNii ID", "nameIdentifierURI": "http://ci.nii.ac.jp/nrid/9000005189344"}]}, {"creatorNames": [{"creatorName": "岡田, 知晃"}], "nameIdentifiers": [{"nameIdentifier": "45618", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "山田, 容子"}], "nameIdentifiers": [{"nameIdentifier": "45619", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "9000314064178", "nameIdentifierScheme": "CiNii ID", "nameIdentifierURI": "http://ci.nii.ac.jp/nrid/9000314064178"}]}, {"creatorNames": [{"creatorName": "宇野, 英満"}], "nameIdentifiers": [{"nameIdentifier": "45620", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "9000018767432", "nameIdentifierScheme": "CiNii ID", "nameIdentifierURI": "http://ci.nii.ac.jp/nrid/9000018767432"}]}, {"creatorNames": [{"creatorName": "豊田, 栄子"}], "nameIdentifiers": [{"nameIdentifier": "45621", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-12-18"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "32-18.pdf", "filesize": [{"value": "185.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "Copyright (c) 2014 by Fukuyama University", "licensetype": "license_free", "mimetype": "application/pdf", "size": 185400.0, "url": {"label": "波多江典之(発表論文抄録(2013))", "url": "https://fukuyama-u.repo.nii.ac.jp/record/8732/files/32-18.pdf"}, "version_id": "27e8f749-7dde-4329-aff4-a675baaba704"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Antineoplastic Agents", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Apoptosis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "HCT116 Cells", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "HL-60 Cells", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Humans", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Inhibitory Concentration 50", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Molecular Structure", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Neoplasms", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Phenanthrenes", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "9,10-フェナンスリジン類によるHCT-116およびHL-60細胞のアポトーシスの誘導(発表論文抄録(2013))", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "9,10-フェナンスリジン類によるHCT-116およびHL-60細胞のアポトーシスの誘導(発表論文抄録(2013))"}, {"subitem_title": "Effect of the orthoquinone moiety in 9,10-phenanthrenequinone on the ability to induce in HCT-116 and HL-60 cells.", "subitem_title_language": "en"}]}, "item_type_id": "10002", "owner": "18", "path": ["782"], "permalink_uri": "https://fukuyama-u.repo.nii.ac.jp/records/8732", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-12-18"}, "publish_date": "2017-12-18", "publish_status": "0", "recid": "8732", "relation": {}, "relation_version_is_last": true, "title": ["9,10-フェナンスリジン類によるHCT-116およびHL-60細胞のアポトーシスの誘導(発表論文抄録(2013))"], "weko_shared_id": -1}
9,10-フェナンスリジン類によるHCT-116およびHL-60細胞のアポトーシスの誘導(発表論文抄録(2013))
https://fukuyama-u.repo.nii.ac.jp/records/8732
https://fukuyama-u.repo.nii.ac.jp/records/873202507436-7ddb-4e5b-9272-7d24641c7516
名前 / ファイル | ライセンス | アクション |
---|---|---|
波多江典之(発表論文抄録(2013)) (185.4 kB)
|
Copyright (c) 2014 by Fukuyama University
|
Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-12-18 | |||||
タイトル | ||||||
タイトル | 9,10-フェナンスリジン類によるHCT-116およびHL-60細胞のアポトーシスの誘導(発表論文抄録(2013)) | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Effect of the orthoquinone moiety in 9,10-phenanthrenequinone on the ability to induce in HCT-116 and HL-60 cells. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Antineoplastic Agents | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Apoptosis | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | HCT116 Cells | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | HL-60 Cells | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Humans | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Inhibitory Concentration 50 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Molecular Structure | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Neoplasms | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Phenanthrenes | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
波多江, 典之
× 波多江, 典之× 中村, 純× 奥島, 鉄雄× 石倉, 稔× 阿部, 匠× 日比野, 俐× 町支, 臣成× 岡田, 知晃× 山田, 容子× 宇野, 英満× 豊田, 栄子 |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 9,10-Phenanthrenequinone (9,10-PQ) is one of the most abundant quinones among diesel exhaust particulates. Recent data have suggested that quinones induce apoptosis in immune, epithelial and tumor cells, leading to respirator illness; however, the mechanisms by which quinones induce apoptosis and the structure required for this remain unknown. We studied the antitumor activity of 9,10-PQ analogs against two human tumor cell lines, HCT-116 colon tumor cells and HL-60 promyelocytic leukemia cells. The loss of the cis-orthoquinone unit in 9,10-PQ abrogated its ability to induce apoptosis in the two tumor cell lines, and the LC50 values of these analogs were indicated over 10 μM. An analog of 9,10-PQ in which the biaryl unit had been deleted displayed a reduced ability to induce tumor cell apoptosis, while the analogs 1,10-phenanthroline-5,6-dione (9) and pyrene-4,5-dione (10), which also had modified biaryl units, exhibited increased tumor cell apoptotic activity. The cis-orthoquinone unit in 9,10-PQ was identified as essential for its ability to induce apoptosis in tumor cells, and its biaryl unit is also considered to influence orthoquinone-mediated apoptotic activity. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 9,10-Phenanthrenequinone (9,10-PQ) is one of the most abundant quinones among diesel exhaust particulates. Recent data have suggested that quinones induce apoptosis in immune, epithelial and tumor cells, leading to respirator illness; however, the mechanisms by which quinones induce apoptosis and the structure required for this remain unknown. We studied the antitumor activity of 9,10-PQ analogs against two human tumor cell lines, HCT-116 colon tumor cells and HL-60 promyelocytic leukemia cells. The loss of the cis-orthoquinone unit in 9,10-PQ abrogated its ability to induce apoptosis in the two tumor cell lines, and the LC50 values of these analogs were indicated over 10 μM. An analog of 9,10-PQ in which the biaryl unit had been deleted displayed a reduced ability to induce tumor cell apoptosis, while the analogs 1,10-phenanthroline-5,6-dione (9) and pyrene-4,5-dione (10), which also had modified biaryl units, exhibited increased tumor cell apoptotic activity. The cis-orthoquinone unit in 9,10-PQ was identified as essential for its ability to induce apoptosis in tumor cells, and its biaryl unit is also considered to influence orthoquinone-mediated apoptotic activity. | |||||
書誌情報 |
福山大学薬学部研究年報 en : Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University 号 32, p. 18-19, 発行日 2014-12-25 |
|||||
出版者 | ||||||
出版者 | 福山大学薬学部 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0288-724X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10064550 |