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カチキン類の細胞透過に及ぼすカテキン構造中のガレート基の影響(発表論文抄録(2008))
https://fukuyama-u.repo.nii.ac.jp/records/8570
https://fukuyama-u.repo.nii.ac.jp/records/8570ad2c757f-126c-47a6-a664-7c8833c451b0
名前 / ファイル | ライセンス | アクション |
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カチキン類の細胞透過に及ぼすカテキン構造中のガレート基の影響 (63.2 kB)
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Copyright (c) 2009 by Fukuyama University
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2017-01-26 | |||||
タイトル | ||||||
タイトル | カチキン類の細胞透過に及ぼすカテキン構造中のガレート基の影響(発表論文抄録(2008)) | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Presence or absence of a gallate moiety on catechins affects their cellular transport. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | ATP-Binding Cassette Transporters | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Biological Transport | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Caco-2 Cells | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Catechin | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Humans | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Multidrug Resistance-Associated Proteins | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Neoplasm Proteins | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | P-Glycoprotein | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
門脇, 正明
× 門脇, 正明× 杉原, 成美× 田頭, 知彦× 寺尾, 和美× 古野, 浩二 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The accumulation of (-)-epicatechin (EC), a non-gallate catechin, was significantly lower than that of (-)-epicatechin gallate (ECG), a gallate catechin, in Caco-2 cells. Using Caco-2 cell monolayers cultured in transwells, the transport of catechins in the basolateral-to-apical direction was much higher than that in the apical-to-basolateral direction, suggesting the involvement of an efflux transporter. Moreover, the results suggest that involvement of a transporter in EC efflux is greater than that for ECG. Treatment with transporter inhibitors MK571, quinidine or mitoxantrone, which inhibit MRP2, P-glycoprotein (P-gp) and BCRP, respectively, led to an increase in the accumulation of EC into Caco-2 cells and a decrease in the Papp ratio (Papp B-->A/Papp A-->B) for EC. These transporters seemed to be involved in EC efflux. BCRP was not an efflux transporter for ECG, and the influences of MRP2 and P-gp on ECG efflux were lower than for EC. Thus, efflux transporters appear to be responsible for the difference in cellular accumulation of EC versus ECG, suggesting that the presence or absence of a gallate moiety in the catechin structure influences the transporters. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The accumulation of (-)-epicatechin (EC), a non-gallate catechin, was significantly lower than that of (-)-epicatechin gallate (ECG), a gallate catechin, in Caco-2 cells. Using Caco-2 cell monolayers cultured in transwells, the transport of catechins in the basolateral-to-apical direction was much higher than that in the apical-to-basolateral direction, suggesting the involvement of an efflux transporter. Moreover, the results suggest that involvement of a transporter in EC efflux is greater than that for ECG. Treatment with transporter inhibitors MK571, quinidine or mitoxantrone, which inhibit MRP2, P-glycoprotein (P-gp) and BCRP, respectively, led to an increase in the accumulation of EC into Caco-2 cells and a decrease in the Papp ratio (Papp B-->A/Papp A-->B) for EC. These transporters seemed to be involved in EC efflux. BCRP was not an efflux transporter for ECG, and the influences of MRP2 and P-gp on ECG efflux were lower than for EC. Thus, efflux transporters appear to be responsible for the difference in cellular accumulation of EC versus ECG, suggesting that the presence or absence of a gallate moiety in the catechin structure influences the transporters. | |||||
書誌情報 |
福山大学薬学部研究年報 en : Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University 号 27, p. 38-38, 発行日 2009-12-25 |
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出版者 | ||||||
出版者 | 福山大学薬学部 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0288-724X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN10064550 |